Neutral ceramidase is a marker for cognitive performance in rats and monkeys
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چکیده
منابع مشابه
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متن کاملCDase is a pan-ceramidase in Drosophila
Ceramidases catalyze the conversion of ceramide to sphingosine. They are acylaminohydrolases that catalyze the deacylation of the amide-linked saturated fatty acid from ceramide to generate sphingosine. They also catalyze the reverse reaction of ceramide biosynthesis using sphingosine and fatty acid. In mammals, different proteins catalyze these reactions while individually exhibiting optimal a...
متن کاملNeutral ceramidase activity inhibition is involved in palmitate-induced apoptosis in INS-1 cells.
Neutral ceramidase (NCDase) is a class of ceramidases, a key enzyme in ceramide degradation. Recently, it was observed that NCDase activity was suppressed by saturated fatty acids to increase ceramide content in rat muscle. However, little is known about its changes in activity and roles in palmitate (Palm)-induced lipotoxicity in pancreatic β cells. Here, we demonstrated that Palm treatment si...
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ژورنال
عنوان ژورنال: Pharmacological Reports
سال: 2020
ISSN: 1734-1140,2299-5684
DOI: 10.1007/s43440-020-00159-2